|
|
 |
|
c19t3P1 (case 3585): The epidermis shows partial effacement of rete ridges over a dermal component. The epidermis shows lentiginous and junctional patterns. There are moderate lymphoid infiltrates beyond the component in the dermis (on the left). Beneath the dermal component, the lymphoid infiltrates are mild. In the dermis, the neoplastic cells form sheets, but there are focal nesting patterns.
|
|
 |
|
|
c19t3P2: There are spotty lentiginous and junctional patterns in the epidermis. Atypia is moderate. Rounded, small nests of nevus-like cells are closely spaced in the widened papillary dermis; they extend in the dermis to the deep margin of the field. There is variability in cell size, and some of the patterns in the deeper portion of the lesion could be characterized as maturation. Near the epidermis, the cells forming nests are larger; they have a moderate amount of pale cytoplasm; there is atypia of minimal deviation type. The lesion qualifies as a nevus-like minimal deviation melanoma and, in this field, the pattern is at least level III.
|
|
|
c19t3P3: The lesion has well defined nevus-like qualities with areas of maturation near its deep margin. Lymphoid infiltrates are mild. Cytologic features are bland and uniform.
|
|
|
c19t3P4: The epidermis is thin with a straight interface. Uniform, moderately atypical cells extend in sheet-like patterns to the dermal-epidermal interface. In this field, a dermal variant of MDM could not be ruled out. The cells have moderately enlarged nuclei that are round or ovoid; some are deeply grooved. Many of the cells have well defined cell membranes in nevus cell-like patterns. There is some variation in nuclear size and staining.
|
|
|
c19t3P5: Small nests of uniform, moderately atypical melanocytic cells are closely spaced in a scanty fibrous stroma. Near the top of the field, the cells are larger; they have more abundant cytoplasm than the cells near the bottom of the field (pattern of maturation). This common nevus-like MDM measured 1.31 mm in vertical dimensions. Thirty months after the excision of this lesion, the patient returned with a metastasis to the central nervous system.
|
|
